The Pandemic Institute’s Public Steering Group recently visit the Liverpool School of Tropical Medicine (LSTM) to hear about pioneering research using organoids – tiny three-dimensional clusters of cells that mimic how tissues behave in the human body. The group also had the opportunity to feedback to the researchers their views on the work and its potential uses for the future.

The session explored the work of LSTM researchers Professor Giancarlo Biagini, Pro Vice-Chancellor for Research and Innovation, Dr Shaun Pennington, Lecturer in Infection and Immunity, and Dr Claire Caygill, Post-Doctoral Research Associate. It offered an in-depth look at how this organoid technology is transforming the study of infectious diseases. Using donated cells, researchers can now grow miniature models of organs such as the liver, lungs and gut in the laboratory. These “micro-organs” make it possible to test new medicines and study how disease-causing pathogens, such as bacteria, viruses and parasites, interact with human tissues, all without the need for animal models.

During facilitated discussion, the group explored the ethical concerns of organoid research, raising questions about how donated cells are sourced, the importance of informed consent, and the need for clear communication about scientific goals.

Professor Biagini explained:

“Engaging directly with the Public Steering Group has been incredibly valuable for our research. These conversations remind us that scientific innovation doesn’t happen in isolation; it must be guided by the people it ultimately aims to serve. Hearing public perspectives helps us to refine our questions, communicate our goals more clearly, and ensure that our work remains ethically grounded and socially relevant.”

The commitment to transparency and public engagement is a main driver for the creation of the public steering group. The group brings together members from across the Liverpool City Region, each bringing their lived experience and community perspectives to inform pandemic-related research. Established in January this year, the group works alongside The Pandemic Institute to make sure that the public’s voice is represented in what we do as an organisation.

The COVID-19 pandemic revealed just how vital public understanding and community trust are to an effective pandemic response. This group aims to create a direct connection between the public and pandemic research, ensuring that science reflects societal needs and values.

Through four meetings each year, members explore key questions such as:

• How can we better prepare for future pandemics and emerging infections?
• What kinds of information and communication build public trust during crises?
• Which areas of research should be prioritised to support community resilience and recovery?

These meetings are run in collaboration with Glenn Skelhorn from The Thinker Hub CIC, a community organisation that facilitates open discussions around “big” ethical and social questions. The sessions are designed not only to gather opinions but also to empower participants – helping members develop critical thinking and discussion skills while gaining insight into how research is designed, funded, and carried out.

Becky Glennon-Alty, Communications Manager at The Pandemic Institute, explains that the group is central to how the Institute ensures accountability and inclusivity:

“Our goal is to bring science and society closer together. The Steering Group allows us to test ideas, share progress, and hear directly from people about what matters most to their communities.”

As well as discussions on organoid research, the group had the opportunity to visit some working research laboratories at LSTM, including the Containment Level 3 (CL3) Laboratories. When working with potentially infectious pathogens (bacteria or viruses), containment measures are used to ensure risk to workers and the wider public are minimised. Laboratories in the UK are classified by four different containment levels, all with varying safety features. CL3 laboratories can handle more serious pathogens, and require a suite of safety features, including negative pressure inside lab spaces, special microbiological safety cabinets, specialist training and restricted access. LSTM are currently building new specialist CL3 robotic labs that will accelerate development of new treatments for deadly diseases.

If you are interested in working with the steering group, as either a researcher or member of the public, please get in touch with us on [email protected].